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KMID : 1149120200170010023
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Journal of the Korean Society for Psoriasis
2020 Volume.17 No. 1 p.23 ~ p.25
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A Case of Paradoxical Cutaneous Sarcoidosis Induced by Adalimumab
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Seo Byeong-Hak
Oh Yong-Woo
Kim Dong-Hee
Seo Ho-Seok
Choi Yu-Sung
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Abstract
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Adalimumab is a recombinant human IgG monoclonal antibody, which selectively blocks tumor necrosis factor-α and has been used for the treatment of immune-mediated diseases. Sarcoidosis is known as a target of adalimumab but we present a patient who has developed cutaneous sarcoidosis during adalimumab therapy. A 37-year-old man presented with 10-month history of scattered, erythematous nodules on both extremities. He had started adalimumab therapy for ankylosing spondylitis 1.5 year ago. Histopathologic findings showed multiple non-caseating granulomatous inflammations. Radiologic finding was normal. He was diagnosed with paradoxical cutaneous sarcoidosis induced by adalimumab. He stopped adalimumab and treated with intralesional corticosteroid injections.
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KEYWORD
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Adalimumab, Cutaneous sarcoidosis, Paradoxical reaction
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